Mitochondrial Dysfunction & Neurological Disorders
نویسنده
چکیده
Most of the living organisms derive their energy requirements from ingested food material through controlled metabolic reactions. Prokaryotes like bacteria obtain the ATP, the energy subunit from series of enzymatic reactions which occur in the cytosol [1]. In contrast to prokaryotes, eukaryotes have evolved a highly specialized double membrane organelles i.e., mitochondria encompassing electron transport chain complexes to harness the electrochemical energy in the reducing equivalents to generate ATP [2]. Thus, mitochondria are vital organelles responsible for providing the energy currency in the form of ATP to sustain various cellular processes. Disturbances or damage to mitochondria results in altered bioenergetics, redox equilibrium and dynamics of cell and is thus identified to be the focal point of pathogenesis in many human diseases including neurological disorders [3].
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